Potassium Hydroxide → O-Coumaric Acid

HRID 1870576

반응식

HRID 1870576 반응식
C([O:3][C:4](=[O:14])[CH:5]=[CH:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[OH:13])C.[OH-].[K+]>C(O)C.O>[OH:13][C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=1/[CH:6]=[CH:5]/[C:4]([OH:14])=[O:3]

참가 물질

5

반응물 2

HCID 14797Potassium HydroxideHCID 576496Ethyl 3-(2-hydroxyphenyl)prop-2-enoate

생성물 1

HCID 637540O-Coumaric Acid수율 51.9%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

To a solution of 100.0 g 3-(2-hydroxy-phenyl)-acrylic acid ethyl ester in 500 ml of ethanol, a solution of 50.9 g potassium hydroxide in 500 ml of water was dropped in at room temperature. After stirring at reflux for 28 hours, the reaction mixture was concentrated. The residue was diluted with 500 ml HCl 2N and extracted with ether. The organic phase was washed with 2N HCl and water, dried and evaporated to dryness. The resulting solid was recrystallized to yield 44.3 g of colourless crystals.

후처리

  1. temperatureat reflux for 28 hours
  2. concentrationthe reaction mixture was concentrated
  3. additionThe residue was diluted with 500 ml HCl 2N
  4. extractionextracted with ether
  5. washThe organic phase was washed with 2N HCl and water
  6. customdried
  7. customevaporated to dryness
  8. customThe resulting solid was recrystallized

출처 및 근거

ORD 기록
ord-d15b5863f9d84dc9ac9ba57a6513e3e7
출처 데이터셋
uspto-grants-2000_08
특허 번호
US06096918

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