9-Decen-1-ol → 2-Propenoic acid, 3-(2-hydroxyphenyl)-, 9-decen-1-yl ester, (2E)-

HRID 1870577

반응식

HRID 1870577 반응식
[CH2:1]([O:3][C:4](=[O:14])[CH:5]=[CH:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[OH:13])[CH3:2].[CH2:15](O)[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22]C=C>CCOCC>[CH2:1]([O:3][C:4](=[O:14])/[CH:5]=[CH:6]/[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[OH:13])[CH2:2][CH2:22][CH2:21][CH2:20][CH2:19][CH2:18][CH2:17][CH:16]=[CH2:15]

참가 물질

4

반응물 2

HCID 256129-Decen-1-olHCID 576496Ethyl 3-(2-hydroxyphenyl)prop-2-enoate

생성물 1

HCID 177820092-Propenoic acid, 3-(2-hydroxyphenyl)-, 9-decen-1-yl ester, (2E)-수율 21.5%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

반응 조건

온도
150 °C

실험 절차

A mixture of 5.0 g 3-(2-hydroxy-phenyl)-acrylic acid ethyl ester, 6.1 g dec-9-en-1-ol and 1.0 g tetraisopropyl-ortho-titanate was heated to 150° C. removing the ethanol formed. After stirring for 2.5 hours at this temperature, the reaction mixture was cooled, diluted with ether and washed with brine. The organic phase was dried and evaporated to dryness. The resulting oil was Kugelrohr-distilled, crystallized and recrystallized to yield 1.69 g of colourless crystals.

후처리

  1. customremoving the ethanol
  2. customformed
  3. temperaturethe reaction mixture was cooled
  4. washwashed with brine
  5. customThe organic phase was dried
  6. customevaporated to dryness
  7. distillationThe resulting oil was Kugelrohr-distilled
  8. customcrystallized
  9. customrecrystallized

출처 및 근거

ORD 기록
ord-af660bd7cf184a139868a73e7f4c1c21
출처 데이터셋
uspto-grants-2000_08
특허 번호
US06096918

연결된 노트

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