Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
p-Bromochlorobenzene → 3-(4-Chlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octan-3-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | p-Bromochlorobenzene | HCID 7806 | — |
| 반응물 | Npc164516 | HCID 79038 | — |
| 반응물 | Butyllithium | HCID 178418339 | — |
| 생성물 | 3-(4-Chlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octan-3-ol | HCID 434488 | — |
반응 단계
The title compound was prepared from 4-bromochlorobenzene (15.4 g, 81 mmol), n-butyllithium in hexanes (31 mL 2.5 M; 78 mmol) and 8-methyl-8-azabicyclo[3.2.1]-octan-3-one (5 g, 36 mmol). Yield 5.7 g (63%) as a white solid, m.p. 186.3-187° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06100275 |
| 출처 데이터셋 | uspto-grants-2000_08 |
| ORD ID | ord-63b26ae4dca64bc48bf0ca3ebfb11381 |
| 출처 메모 | uspto-grants-2000_08 |