Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Norchlorcyclizine → Cetirizine methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Norchlorcyclizine | HCID 9340 | — |
| 반응물 | Methyl 2-(2-chloroethoxy)acetate | HCID 15337474 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | Cetirizine methyl ester | HCID 608480 | — |
반응 단계
10 gr. of (0.035 mole) of 1-[(4-chlorophenyl)phenylmethyl]piperazine, 8.06 gr. (0.0525 mole) of methyl 2-chloroethoxyacetate and 50 ml. of triethylamine were introduced into a pressure vessel and treated in a similar way as described in example 1. 12.5 gr. of methyl [2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetate is obtained as reddish oil (88.7% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06100400 |
| 출처 데이터셋 | uspto-grants-2000_08 |
| ORD ID | ord-950f1ae5ba8a4647af578eb869f7464a |
| 출처 메모 | uspto-grants-2000_08 |