Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Carbonate → 4-(3,4-Dichlorophenyl)-1-piperazinepentanenitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 5-Chlorovaleronitrile | HCID 80474 | — |
| 반응물 | 1-(3,4-Dichlorophenyl)piperazine | HCID 93601 | — |
| 촉매 | Potassium Iodide | HCID 4875 | — |
| 용매 | Methyl Isobutyl Ketone | HCID 7909 | — |
| 생성물 | 4-(3,4-Dichlorophenyl)-1-piperazinepentanenitrile | HCID 21999698 | 72.1% |
반응 단계
A mixture of 1-(3,4-dichlorophenyl)piperazine (0.1 mol), 5-chloropentanenitrile (0.13 mol), sodium carbonate (10 g) and potassium iodide (0.1 g) in 4-methyl-2-pentanone (280 ml) was stirred and refluxed for 10 hours. The reaction mixture was cooled, filtered and the filtrate was evaporated. The residue was purified by column chromatography over silica gel (eluent: CH2Cl2 /CH3OH 95/5). The pure fractions were collected and the solvent was evaporated, yielding 22.5 g (72%) of 4-(3,4-dichlorophenyl)-1-piperazinepentanenitrile (interm. 2).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06103725 |
| 출처 데이터셋 | uspto-grants-2000_08 |
| ORD ID | ord-291ac4da5fee4cedb4d5e4a202d56366 |
| 출처 메모 | uspto-grants-2000_08 |