(Tetrahydro-2H-pyran-4-yl)hydrazine → (cis)-4-(3,4-Dimethoxyphenyl)-2-(tetrahydropyran-4-yl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one

HRID 1871442노트

반응식

HRID 1871442 반응식
[NH:1]([CH:3]1[CH2:8][CH2:7][O:6][CH2:5][CH2:4]1)[NH2:2].[CH3:9][O:10][C:11]1[CH:12]=[C:13]([C:19]2[C@H:28]3[C@H:23]([CH2:24][CH2:25][CH2:26][CH2:27]3)[C:22](=[O:29])N(CCO)N=2)[CH:14]=[CH:15][C:16]=1[O:17][CH3:18]>>[CH3:9][O:10][C:11]1[CH:12]=[C:13]([C:19]2[C@H:28]3[C@H:23]([CH2:24][CH:25]=[CH:26][CH2:27]3)[C:22](=[O:29])[N:1]([CH:3]3[CH2:8][CH2:7][O:6][CH2:5][CH2:4]3)[N:2]=2)[CH:14]=[CH:15][C:16]=1[O:17][CH3:18]

참가 물질

3

반응물 2

HCID 10057480(Tetrahydro-2H-pyran-4-yl)hydrazineHCID 86755609(cis)-4-(3,4-Dimethoxyphenyl)-2-(2-hydroxy-1-ethyl)-4a,5,6,7,8,8a-hexahydro-2H-phthalazin-1-one

생성물 1

HCID 86755631(cis)-4-(3,4-Dimethoxyphenyl)-2-(tetrahydropyran-4-yl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one

실험 절차

Prepared from compound C and 4-hydrazinotetrahydropyran as described for compound 35. Crystallized from methanol. M.p. 175°-177° C.

후처리

  1. customCrystallized from methanol

출처 및 근거

ORD 기록
ord-3215fb063ad84d429105f334f9a0091c
출처 데이터셋
uspto-grants-2000_08
특허 번호
US06103718

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