Water → HCID 18689385, 화합물

HRID 1871843노트

반응식

HRID 1871843 반응식
[CH:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[C:2]1=[C:11]1[C:15]([CH3:17])([CH3:16])[O:14][C:13]([C:18]3[CH:23]=[CH:22][CH:21]=[C:20]([O:24]C)[CH:19]=3)=[N:12]1)[CH2:8]2.B(I)(I)I.O>C(Cl)Cl>[CH:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[C:2]1=[C:11]1[C:15]([CH3:17])([CH3:16])[O:14][C:13]([C:18]3[CH:23]=[CH:22][CH:21]=[C:20]([OH:24])[CH:19]=3)=[N:12]1)[CH2:8]2

참가 물질

5

반응물 3

HCID 962Water2회HCID 83546Borane, triiodo-HCID 18689382HCID 18689382, 화합물

생성물 1

HCID 18689385HCID 18689385, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of 7 mmol 4-adamantylidene-2-(3'-methoxyphenyl)-5,5-dimethyl-oxazoline in 20 ml absolute methylene chloride is added dropwise to a solution of 14 mmol boron triiodide while stirring at -25° C. with the exclusion of air and water. The mixture is heated to room temperature within one hour and stirred for a further 4 h. After admixing with 50 ml water the organic phase is separated and dried over sodium sulfate. The solvent is removed by distillation. The oily residue is separated by column chromatography (silica gel: ethyl acetate/petroleum ether 1:3).

후처리

  1. customis separated
  2. dry with materialdried over sodium sulfate
  3. customThe solvent is removed by distillation
  4. customThe oily residue is separated by column chromatography (silica gel: ethyl acetate/petroleum ether 1:3)

출처 및 근거

ORD 기록
ord-12c853bd71b7413486a92e4a70faa90d
출처 데이터셋
uspto-grants-2000_08
특허 번호
US06107036

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