3-(Isoquinolin-4-yl)-8-methyl-8-azabicyclo[3.2.1]oct-2-ene → HCID 18689915, 화합물
반응식
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]2[CH2:17][CH:16]3[N:18]([CH3:19])[CH:13]([CH2:14][CH2:15]3)[CH:12]=2)=[CH:3][N:2]=1>CO>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([CH:11]2[CH2:17][CH:16]3[N:18]([CH3:19])[CH:13]([CH2:14][CH2:15]3)[CH2:12]2)=[CH:3][N:2]=1참가 물질
3
실험 절차
A mixture 3-(isoquinolin-4-yl)-8-methyl-8-azabicyclo[3.2.1]oct-2-ene and 5-palladium on carbon in methanol is stirred at room temperature for 3 days under a hydrogen atmosphere. The reaction mixture is then filtered and the filtrate concentrated under reduced pressure. The residue is subjected to flash silica gel chromatography. Fractions containing product are combined and concentrated under reduced pressure to provide the title compound.
후처리
- filtrationThe reaction mixture is then filtered
- concentrationthe filtrate concentrated under reduced pressure
- additionFractions containing product