Trifluoroacetic acid → HCID 18689938, 화합물

HRID 1871922노트

반응식

HRID 1871922 반응식
C(OC([N:8]1[CH2:13][CH2:12][C:11](=[CH:14][C:15]2[CH:24]=[CH:23][C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[N:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>ClCCl>[N:16]1[C:17]2[C:22](=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:23]=[CH:24][C:15]=1[CH:14]=[C:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 18689933HCID 18689933, 화합물

생성물 1

HCID 18689938HCID 18689938, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

1-tert-Butoxycarbonyl-4-(2-quinolylmethylene)piperidine (17.6 g) was dissolved in dichloromethane (60 ml), and TFA (60 ml) was added to the solution under cooling on ice. The mixture was stirred for 2.5 hours at room temperature and concentrated under reduced pressure. A saturated solution of sodium hydrogencarbonate was added to the residue to neutralize, and the mixture was then extracted with chloroform. The organic phase was dried over sodium sulfate anhydrate and concentrated under reduced pressure. The title compound was recovered from an etherhexane solvent as white powder. This powder was also used for subsequent reaction without further purification.

후처리

  1. temperatureunder cooling on ice
  2. concentrationconcentrated under reduced pressure
  3. additionA saturated solution of sodium hydrogencarbonate was added to the residue
  4. extractionthe mixture was then extracted with chloroform
  5. dry with materialThe organic phase was dried over sodium sulfate anhydrate
  6. concentrationconcentrated under reduced pressure
  7. customThe title compound was recovered from an etherhexane solvent as white powder
  8. customThis powder was also used for subsequent reaction without further purification

출처 및 근거

ORD 기록
ord-608e8741f1bb4b8bb7d3396782077e66
출처 데이터셋
uspto-grants-2000_08
특허 번호
US06107308

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