Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(Bromomethyl)-3-ethylbenzene → 2-[2-[2-(3-Ethylphenyl)ethyl]-4-methylphenyl]-4,5-dihydro-4,4-dimethyloxazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(Bromomethyl)-3-ethylbenzene | HCID 22003656 | — |
| 반응물 | 2-[2,4-Dimethylphenyl]-4,5-dihydro-4,4-dimethyloxazole | HCID 22117273 | — |
| 반응물 | Butyllithium | HCID 178418339 | — |
| 용매 | 2-Methylpentane | HCID 7892 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 2-[2-[2-(3-Ethylphenyl)ethyl]-4-methylphenyl]-4,5-dihydro-4,4-dimethyloxazole | HCID 18689713 | — |
반응 단계
n-Butyllithium (16.8 ml of a 2.5M solution in isohexane) was added dropwise to a stirred solution of the product of step (iii) (8.13 g) in dry tetrahydrofuran (ISOml) at 0° C. under nitrogen. After 1 hour, the product of step (ii) (8.0 g) in tetrahydrofliran (60 ml) was added. After 1 hour, the reaction was quenched with aqueous ammonium chloride and partitioned between ethyl acetate and water. The organic solution was dried (MgSO4) and evaporated. Purification was by chromatography eluting with 5% ethyl acetate in isohexane. Yield 4.93 g.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06107297 |
| 출처 데이터셋 | uspto-grants-2000_08 |
| ORD ID | ord-6131338cbdc04d71916f960b0699ee4f |
| 출처 메모 | uspto-grants-2000_08 |