Methanol → N-[2-[5-{2,8-Dimethyl-5H-dibenzo[a,d]cyclohepten-5-yl}-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl]-5-[methoxycarbonyl]pyrimidin-4-yl]glycine

HRID 1871988노트

반응식

HRID 1871988 반응식
[CH3:1][C:2]1[CH:44]=[CH:43][C:5]2[CH:6]([C:16]3[C:17](=[O:42])[NH:18][C:19](=[O:41])[N:20]([C:22]4[N:27]=[C:26]([NH:28][CH2:29][C:30]([O:32]C(C)(C)C)=[O:31])[C:25]([C:37]([O:39][CH3:40])=[O:38])=[CH:24][N:23]=4)[CH:21]=3)[C:7]3[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][C:8]=3[CH:9]=[CH:10][C:4]=2[CH:3]=1.CO>FC(F)(F)C(O)=O.ClCCl>[CH3:15][C:12]1[CH:13]=[CH:14][C:7]2[CH:6]([C:16]3[C:17](=[O:42])[NH:18][C:19](=[O:41])[N:20]([C:22]4[N:27]=[C:26]([NH:28][CH2:29][C:30]([OH:32])=[O:31])[C:25]([C:37]([O:39][CH3:40])=[O:38])=[CH:24][N:23]=4)[CH:21]=3)[C:5]3[CH:43]=[CH:44][C:2]([CH3:1])=[CH:3][C:4]=3[CH:10]=[CH:9][C:8]=2[CH:11]=1

참가 물질

5

반응물 2

HCID 887MethanolHCID 867556552-[5-{2,8-Dimethyl-5H-dibenzo[a,d]cyclohepten-5-yl}-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl]-4-[[[1,1-dimethylethoxy]carbonylmethyl]amino]-5-pyrimidinecarboxylic acid, methyl ester

생성물 1

HCID 18689752N-[2-[5-{2,8-Dimethyl-5H-dibenzo[a,d]cyclohepten-5-yl}-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl]-5-[methoxycarbonyl]pyrimidin-4-yl]glycine

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 6422Trifluoroacetic acid용매

실험 절차

A mixture of the product of step (iii) (0.57 g) in trifluoroacetic acid (5 ml) and dichloromethane (10 ml) was stirred at room temperature for 5 hours. Methanol (30 ml) was added and the precipitate collected. The solid was dissolved in methanol and sodium hydroxide solution and the product precipitated out by addition of 2M HCl. Yield 0.26 g.

후처리

  1. customthe precipitate collected
  2. dissolutionThe solid was dissolved in methanol
  3. customsodium hydroxide solution and the product precipitated out by addition of 2M HCl

출처 및 근거

ORD 기록
ord-fddf329857be4daf8cbe19cc593f37e6
출처 데이터셋
uspto-grants-2000_08
특허 번호
US06107297

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