HCID 86755658, 화합물 → HCID 86755659, 화합물

HRID 1871995노트

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HRID 1871995 반응식
[CH2:1]([C:3]1[CH:50]=[CH:49][C:6]2[CH:7]([C:17]3[C:18]([S:47]C)=[N:19][C:20](=[O:46])[N:21]([C:23]4[CH:28]=[CH:27][N:26]=[C:25]([N:29]([CH3:45])[CH2:30][C:31]([NH:33][C:34]5[S:35][CH:36]=[C:37]([CH2:39][C:40]([O:42][CH2:43][CH3:44])=[O:41])[N:38]=5)=[O:32])[N:24]=4)[CH:22]=3)[C:8]3[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][C:9]=3[CH:10]=[CH:11][C:5]=2[CH:4]=1)[CH3:2]>N1C=CC=CC=1.C(N(CC)CC)C>[CH2:1]([C:3]1[CH:50]=[CH:49][C:6]2[CH:7]([C:17]3[C:18](=[S:47])[NH:19][C:20](=[O:46])[N:21]([C:23]4[CH:28]=[CH:27][N:26]=[C:25]([N:29]([CH3:45])[CH2:30][C:31]([NH:33][C:34]5[S:35][CH:36]=[C:37]([CH2:39][C:40]([O:42][CH2:43][CH3:44])=[O:41])[N:38]=5)=[O:32])[N:24]=4)[CH:22]=3)[C:8]3[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][C:9]=3[CH:10]=[CH:11][C:5]=2[CH:4]=1)[CH3:2]

참가 물질

4

반응물 1

HCID 86755658HCID 86755658, 화합물

생성물 1

HCID 86755659HCID 86755659, 화합물

시약·촉매·용매 2

HCID 1049Pyridine용매HCID 8471Triethylamine용매

실험 절차

The product from step (v) (0.61 g) was dissolved in dry pyridine (20 ml) and triethylamine (1.0 ml). Hydrogen sulphide gas was slowly bubbled through the solution for 15 minutes. The solvents were evaporated under reduced pressure and the residue azeotroped twice with toluene. The residue was purified by chromatography eluting with ethyl acetate in toluene. Yield 0.41 g.

후처리

  1. customHydrogen sulphide gas was slowly bubbled through the solution for 15 minutes
  2. customThe solvents were evaporated under reduced pressure
  3. customthe residue azeotroped twice with toluene
  4. customThe residue was purified by chromatography
  5. washeluting with ethyl acetate in toluene

출처 및 근거

ORD 기록
ord-9b192823e3be4dffaac6af1fb1edc8a0
출처 데이터셋
uspto-grants-2000_08
특허 번호
US06107297

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