1,4-Dioxane hydrochloride → (S)-2-Amino-N,N-dimethyl-4-phenyl-butyramide hydrochloride

반응식

C(OC(=O)[NH:7][C@H:8]([C:17](=[O:21])[N:18]([CH3:20])[CH3:19])[CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)(C)(C)C.[ClH:23].O1CCOCC1>>[ClH:23].[NH2:7][C@@H:8]([CH2:9][CH2:10][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)[C:17]([N:18]([CH3:19])[CH3:20])=[O:21]

참가 물질

반응물 2

HCID 204431481,4-Dioxane hydrochloride

HCID 54369423(S)-(1-Dimethylcarbamoyl-3-phenyl-propyl)-carbamic acid tert-butyl ester

생성물 1

HCID 69688590(S)-2-Amino-N,N-dimethyl-4-phenyl-butyramide hydrochloride

반응 조건

온도: 25 °C

실험 절차

(S)-(1-Dimethylcarbamoyl-3-phenyl-propyl)-carbamic acid tert-butyl ester (235 mg, 0.8 mmol) was dissolved in 4 M HCl-dioxane (2 mL) at 0° C. The mixture was stirred at 25° C. for 1.5 hours, concentrated and the residue triturated with ether. Yield, 187 mg, 100%; HPLC (60/40) 2.31 minutes (99%).

후처리

concentrationconcentrated
customthe residue triturated with ether
customYield

출처 및 근거

ORD 기록: ord-d987e04c6b9346cbbf6c2658da0b1732
출처 데이터셋: uspto-grants-2000_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06107329

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