참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 1-Eth-1-ynyl-4-(pentyloxy)benzene | HCID 2775119 | — |
| 반응물 | alpha-Chloro-4-methoxycarbonylbenzaldoxime | HCID 73989494 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | Methyl 4-(5-(4-(pentyloxy)phenyl)isoxazol-3-yl)benzoate | HCID 10737571 | 84.6% |
반응 단계
To a solution of 4-Methoxycarbonylphenylhydroxyiminomethyl chloride (16.98 g) and 4-n-pentyloxyphenylacetylene (18.96 g) in tetrahydrofuran (170 ml) was added triethylamine (14.4 ml) in tetrahydrofuran (140 ml) over a period of 2 hours at 40° C. and the mixture was stirred at 40° C. for 30 minutes. The mixture was diluted with dichloromethane and washed with water and brine. The separated organic layer was dried over magnesium sulfate and evaporated under reduced pressure. The residue was triturated with acetonitrile. The precipitate was collected by filtration and dried to give Methyl 4-[5-(4-n-pentyloxyphenyl)isoxazol-3-yl]benzoate (24.56 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06107458 |
|---|
| 출처 데이터셋 | uspto-grants-2000_08 |
|---|
| ORD ID | ord-b78335e158dd48b8bd5da9f7ec3aed03 |
|---|
| 출처 메모 | uspto-grants-2000_08 |
|---|
