Sulfuric Acid → Benzamide
반응식
[C:1]([C:3]1[CH:8]=[CH:7][C:6](C(N2C(CC3CCCCC3)C(=O)N3CC4C=CC=CC=4CC3C2=O)C(NCCC2C=CC(F)=CC=2)=O)=[CH:5][CH:4]=1)#[N:2].S(=O)(=O)(O)[OH:46]>>[C:1]([NH2:2])(=[O:46])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1참가 물질
3
실험 절차
This compound was prepared by stirring 2-(4-cyano-phenyl)-2-(3-cyclohexylmethyl-1,4-dioxo-1,3,4,6,11,11a-hexahydro-pyrazino[1,2-b]isoquinolin-2-yl)-N-[2-(4-fluoro-phenyl)-ethyl]-acetamide (305 mg, 0.51 mmol) in 10 ml of concentrated sulfuric acid. After 1 hour the solution was poured into 40 g of ice. The ice melted and the white solid was filtered, dried, and the crude product was purified by flash chromatography (1:20 methanol/dichloromethane; Rf =0.25) to give 60 mg (20%) of 4-{(3-cyclohexylmethyl-1,4-dioxo-1,3,4,6,11,11a-hexahydro-pyrazino[1,2-b]isoquinolin-2-yl)-[2-4-fluoro-phenyl)-ethylcarbamoyl]-methyl}-benzamide.
후처리
- customThis compound was prepared
- filtrationthe white solid was filtered
- customdried
- customthe crude product was purified by flash chromatography (1:20 methanol/dichloromethane; Rf =0.25)