Methyl formate → 5-Diethylphosphono-2-thiophenecarboxaldehyde

HRID 1872511노트

반응식

HRID 1872511 반응식
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[P:6]([O:11][CH2:12][CH3:13])(=[O:10])[O:7][CH2:8][CH3:9].[Li+].CC([N-]C(C)C)C.[CH:22](OC)=[O:23]>O1CCCC1>[CH2:12]([O:11][P:6]([C:2]1[S:1][C:5]([CH:22]=[O:23])=[CH:4][CH:3]=1)([O:7][CH2:8][CH3:9])=[O:10])[CH3:13]

참가 물질

5

반응물 3

HCID 7865Methyl formateHCID 2724682Lithium diisopropylamideHCID 42543912-Diethylphosphonothiophene

생성물 1

HCID 222749525-Diethylphosphono-2-thiophenecarboxaldehyde

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution 1.0 mmol of diethyl 2-thiophenephosphonate in tetrahydrofuran was treated with 1.12 mmol LDA at -78° C. for 20 min. 1.5 mmol methyl formate was added and the reaction was stirred for 1 hr. Extraction and chromotagraphy gave 5-diethylphosphono-2-thiophenecarboxaldehyde as a clear yellow oil.

후처리

  1. extractionExtraction and chromotagraphy

출처 및 근거

ORD 기록
ord-de713f35154e4bdf87aef38d795ab539
출처 데이터셋
uspto-grants-2000_08
특허 번호
US06110903

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