Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diazomethane → 4-Nitro-7-cyclopropyl-5-fluoro-1-isobutyl-2-(2-diethylphosphono-5-furanyl)benzimidazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diazomethane | HCID 9550 | — |
| 반응물 | 4-Nitro-7-vinyl-5-fluoro-1-isobutyl-2-(2-diethylphosphono-5-furanyl)benzimidazole | HCID 54409667 | — |
| 촉매 | palladium(II) acetate | HCID 167845 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 4-Nitro-7-cyclopropyl-5-fluoro-1-isobutyl-2-(2-diethylphosphono-5-furanyl)benzimidazole | HCID 53981592 | — |
반응 단계
To a suspension of 1.0 mmol of 4-nitro-7-vinyl-5-fluoro-1-isobutyl-2-(2-diethylphosphono-5-furanyl)benzimidazole and 0.1 mmol of Pd(OAc)2 in 8 mL of ether was added an ether solution of diazomethane (generated from 3.0 g of 1-methyl-3-nitro-1-nitrosoguanidine) at 0 ° C. After stirring at room temperature 20 h solvent was removed and the residue chromatographed to give 4-nitro-7-cyclopropyl-5-fluoro-1-isobutyl-2-(2-diethylphosphono-5-furanyl)benzimidazole.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06110903 |
| 출처 데이터셋 | uspto-grants-2000_08 |
| ORD ID | ord-87f75d51ad9c4ec3ba4704a2bbeedbdf |
| 출처 메모 | uspto-grants-2000_08 |