5-Aminoisoquinoline → 5-Amino-1,2,3,4-tetrahydroisoquinoline

HRID 1872692노트

반응식

HRID 1872692 반응식
[NH2:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][N:6]=[CH:7]2>C(O)(=O)C.S(=O)(=O)(O)O.[Pt]=O>[NH2:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][NH:6][CH2:7]2

참가 물질

5

반응물 1

HCID 707665-Aminoisoquinoline

생성물 1

HCID 162174995-Amino-1,2,3,4-tetrahydroisoquinoline수율 63.1%

시약·촉매·용매 3

HCID 82844Platinum oxide (PtO)촉매HCID 176Acetic Acid용매HCID 1118Sulfuric Acid용매

실험 절차

A solution of 5-aminoisoquinoline (10 g, 69 mmol) in glacial acetic acid (150 ml) and concentrated sulfuric acid (1 ml) was hydrogenated over platinum oxide (1 g) at 55 psi for 20h. The acetic acid was then removed in vacuo and the residue treated with saturated aqueous potassium carbonate (100 ml) and extracted with dichloromethane. The organic layer was dried over sodium sulfate and concentrated in vacuo to afford the title compound (6.45 g).

후처리

  1. customThe acetic acid was then removed in vacuo
  2. additionthe residue treated with saturated aqueous potassium carbonate (100 ml)
  3. extractionextracted with dichloromethane
  4. dry with materialThe organic layer was dried over sodium sulfate
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-5a34c24bdfef4d0aaf46bd3e42941566
출처 데이터셋
uspto-grants-2000_08
특허 번호
US06110934

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