Cyclohexanemethylamine → tert-butyl (4S,5R)-2-(cyclohexylmethylamino)-4,5-diphenyl-4,5-dihydroimidazole-1-carboxylate

참여 물질

역할	이름	HCID	투입량
반응물	Cyclohexanemethylamine	HCID 76688	—
반응물	cis-4,5-Diphenyl-2-methylthio-4,5-dihydro-imidazole-1-carboxylic Acid, Tert-Butyl Ester	HCID 86596320	—
용매	Methanol	HCID 887	—
생성물	tert-butyl (4S,5R)-2-(cyclohexylmethylamino)-4,5-diphenyl-4,5-dihydroimidazole-1-carboxylate	HCID 68567695	39%

반응 조건

온도	100 °C

반응 단계

A mixture of intermediate 59 (0.5 g, 1.36 mmol), cyclohexanemethylamine (0.53 mL, 6.1 mmol) and MeOH (0.11 mL) is heated at 100° C. for 48 h. The reaction mixture is cooled to RT and purified by chromatography on silica gel; gradient elution with heptane:EtOAc (70:30-50:50) gives 0.23 g of the product 79. 1H NMR (CDCl3) δ 7.80-7.35 (m, 2 H), 7.18 9s, 1 H), 7.10-6.90 (m, 6 H), 6.90-6.70 (m, 2 H), 5.45-5.30 (m, 2 H), 3.45-3.15 (m, 2 H), 2.00-1.50 (m, 5 H), 1.45-0.95 (m, 15H); MS: m/z 434 (M++1).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07741493B2
출처 데이터셋	uspto-grants-2010_06
ORD ID	ord-77af2833d1c347c2b08d7641f38020e5
출처 메모	uspto-grants-2010_06