4-(5-Fluoro-1H-indol-3-YL)cyclohexanone → 3-(4-oxocyclohexyl)-1H-indole-5-carbonitrile

HRID 1872833노트

반응식

HRID 1872833 반응식
FC1C=C2C(=CC=1)NC=C2C1CCC(=O)CC1.C1O[C:21]2([CH2:26][CH2:25][CH:24]([C:27]3[C:35]4[C:30](=[CH:31][CH:32]=[C:33]([C:36]#[N:37])[CH:34]=4)[NH:29][CH:28]=3)[CH2:23][CH2:22]2)[O:20]C1>>[C:36]([C:33]1[CH:34]=[C:35]2[C:30](=[CH:31][CH:32]=1)[NH:29][CH:28]=[C:27]2[CH:24]1[CH2:25][CH2:26][C:21](=[O:20])[CH2:22][CH2:23]1)#[N:37]

참가 물질

3

반응물 2

HCID 107046834-(5-Fluoro-1H-indol-3-YL)cyclohexanoneHCID 155219733-(1,4-Dioxa-spiro[4,5]dec-8-yl)-5-cyano-1H-indole

생성물 1

HCID 112418863-(4-oxocyclohexyl)-1H-indole-5-carbonitrile

실험 절차

This compound was prepared in the manner as described above for (3a) by replacing 4-(5-fluoro-1H-3-indolyl)-cyclohexanone ethylene ketal with 4-(5-cyano-1H-3-indolyl)-cyclohexanone ethylene ketal (6 g) in 81% (4.0 g) of product as a white solid: mp 162.5-164° C.

후처리

  1. customThis compound was prepared in the manner

출처 및 근거

ORD 기록
ord-2d2af9a4a22843a7bbacec252f6804c3
출처 데이터셋
uspto-grants-2000_08
특허 번호
US06110956

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