참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Methyl Acridine-4-carboxylate | HCID 11064418 | — |
| 용매 | Acridone | HCID 2015 | — |
| 생성물 | Acridine-4-carboxylic Acid | HCID 11138739 | 87% |
반응 단계
To methyl acridine-4-carboxylate, prepared in Example 4,(183 mg), was added a degassed solution of NaOH in aqueous EtOH (1:1,2M)(35 ml). The mixture was stirred for 3 hours at 50° C., when a clear solution was obtained, then neutralised with glacial AcOH. Extraction with EtOAc (3×15 50 ml) followed by chromatography on silica gel, eluting with EtOAc/petroleum ether (1:4), gave acridine-4-carboxylic acid (160 mg, 87%), mp (Me2CO) 196-197° C. (lit, mp 202-204° C.).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06111109 |
|---|
| 출처 데이터셋 | uspto-grants-2000_08 |
|---|
| ORD ID | ord-3bd7817617e2472e80674c6f20cd3ecd |
|---|
| 출처 메모 | uspto-grants-2000_08 |
|---|
