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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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2,3-Dihydroxybutanedioic Acid → 5-[2-((2S,4S)-2-cyano-4-fluoro-pyrrolidin-1-yl)-2-oxo-ethylamino]-N,N,5-trimethyl-hexahydro-cyclopenta[c]pyrrole-2-carboxamide tartrate

HRID 1873529
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HRID 1873529 반응식
[C:1]([C@@H:3]1[CH2:7][C@H:6]([F:8])[CH2:5][N:4]1[C:9](=[O:26])[CH2:10][NH:11][C:12]1([CH3:25])[CH2:24][CH:15]2[CH2:16][N:17]([C:19]([N:21]([CH3:23])[CH3:22])=[O:20])[CH2:18][CH:14]2[CH2:13]1)#[N:2].[C:27]([OH:36])(=[O:35])[CH:28]([CH:30]([C:32]([OH:34])=[O:33])[OH:31])[OH:29]>ClCCl.CC(C)=O>[C:32]([CH:30]([CH:28]([C:27]([OH:36])=[O:35])[OH:29])[OH:31])([OH:34])=[O:33].[C:1]([C@@H:3]1[CH2:7][C@H:6]([F:8])[CH2:5][N:4]1[C:9](=[O:26])[CH2:10][NH:11][C:12]1([CH3:25])[CH2:13][CH:14]2[CH2:18][N:17]([C:19]([N:21]([CH3:22])[CH3:23])=[O:20])[CH2:16][CH:15]2[CH2:24]1)#[N:2]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 2

HCID 8752,3-Dihydroxybutanedioic AcidHCID 687768935-[2-((2S,4S)-2-cyano-4-fluoro-pyrrolidin-1-yl)-2-oxo-ethylamino]-N,N,5-trimethyl-hexahydro-cyclopenta[c]pyrrole-2(1H)-carboxamide

생성물 1

HCID 687771195-[2-((2S,4S)-2-cyano-4-fluoro-pyrrolidin-1-yl)-2-oxo-ethylamino]-N,N,5-trimethyl-hexahydro-cyclopenta[c]pyrrole-2-carboxamide tartrate수율 82%

시약·촉매·용매 2

HCID 180Acetone용매
HCID 6344
Dichloromethane
용매

실험 절차

5-[2-((2S,4S)-2-Cyano-4-fluoro-pyrrolidin-1-yl)-2-oxo-ethylamino]-N,N,5-trimethyl-hexahydro-cyclopenta[c]pyrrole-2(1H)-2-carboxamide 13h (0.16 g, 0.44 mmol) was dissolved in 5 mL of dichloromethane with stirring followed by dropwise addition of a solution of 5 mL of tartaric acid (65.6 mg, 0.44 mmol) in acetone. The reaction mixture was reacted for 30 minutes resulting in the formation of a white precipitate. The mixture was filtered and the filter cake was washed with acetone to obtain the title compound 5-[2-((2S,4S)-2-cyano-4-fluoro-pyrrolidin-1-yl)-2-oxo-ethylamino]-N,N,5-trimethyl-hexahydro-cyclopenta[c]pyrrole-2-carboxamide tartrate 13 (0.18 g, yield 82%) as a white solid.

후처리

  1. customThe reaction mixture was reacted for 30 minutes
  2. customresulting in the formation of a white precipitate
  3. filtrationThe mixture was filtered
  4. washthe filter cake was washed with acetone

출처 및 근거

ORD 기록
ord-e220082026f0482b8581d12b7c75ef81
출처 데이터셋
uspto-grants-2012_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08304411B2

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