Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,3-Dichloroacetone → HCID 178455314, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,3-Dichloroacetone | HCID 10793 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | 4-Fluorophenylthiourea | HCID 693061 | — |
| 반응물 | 2-Amino-4-(4-{[tert-butyl(dimethyl)silyl]oxy}cyclohexyl)-6-mercaptopyridine-3,5-dicarbonitrile | HCID 178455031 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | HCID 178455314 | HCID 178455314 | — |
반응 단계
43 mg (0.26 mmol) of 4-fluorophenylthiourea and 31 mg (0.24 mmol) of 1,3-dichloroacetone are dissolved in 2 ml DMF and stirred at +80° C. for 3 h. After cooling to RT 93 mg (0.23 mmol) of the compound from Example 12A (cis isomer) and 78 mg (0.93 mmol) of sodium bicarbonate are added, and the reaction mixture is stirred at RT for 20 h. The mixture is then directly purified by preparative HPLC (column: YMC GEL ODS-AQ S-5/15 μm; mobile phase gradient: acetonitrile/water 10:90→95:5).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08304412B2 |
| 출처 데이터셋 | uspto-grants-2012_11 |
| ORD ID | ord-bf5776ccca9143d58fd8430e59cbccb4 |
| 출처 메모 | uspto-grants-2012_11 |