Sodium Bicarbonate → 2-{4-[2-Amino-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}thio)-3,5-dicyanopyridin-4-yl]-piperidin-1-yl}-2-oxoethyl acetate

HRID 1873574노트

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HRID 1873574 반응식
[C:1]([O:4][CH2:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[C:19]([C:20]#[N:21])=[C:18]([SH:22])[N:17]=[C:16]([NH2:23])[C:15]=2[C:24]#[N:25])[CH2:10][CH2:9]1)=[O:7])(=[O:3])[CH3:2].Cl[CH2:27][C:28]1[N:29]=[C:30]([C:33]2[CH:38]=[CH:37][C:36]([Cl:39])=[CH:35][CH:34]=2)[S:31][CH:32]=1.C(=O)(O)[O-].[Na+]>CN(C=O)C>[C:1]([O:4][CH2:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[C:19]([C:20]#[N:21])=[C:18]([S:22][CH2:27][C:28]3[N:29]=[C:30]([C:33]4[CH:38]=[CH:37][C:36]([Cl:39])=[CH:35][CH:34]=4)[S:31][CH:32]=3)[N:17]=[C:16]([NH2:23])[C:15]=2[C:24]#[N:25])[CH2:10][CH2:9]1)=[O:7])(=[O:3])[CH3:2]

참가 물질

5

반응물 3

HCID 516892Sodium BicarbonateHCID 6102974-(Chloromethyl)-2-(4-chlorophenyl)-1,3-thiazoleHCID 178476478HCID 178476478, 화합물

생성물 1

HCID 687021312-{4-[2-Amino-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}thio)-3,5-dicyanopyridin-4-yl]-piperidin-1-yl}-2-oxoethyl acetate

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

34 mg (0.06 mmol) of the compound from Example 24A are dissolved in 1.2 ml of dry DMF, and 17 mg (0.07 mmol) of 4-(chloromethyl)-2-(4-chlorophenyl)-1,3-thiazole and 19 mg (0.23 mmol) of sodium bicarbonate are added. The reaction mixture is stirred at RT for 8 h. The mixture is then filtered, and about 0.5 ml of water is added to the filtrate. The precipitate formed is filtered off with suction and dried under reduced pressure at +50° C.

후처리

  1. filtrationThe mixture is then filtered
  2. additionabout 0.5 ml of water is added to the filtrate
  3. customThe precipitate formed
  4. filtrationis filtered off with suction
  5. customdried under reduced pressure at +50° C.

출처 및 근거

ORD 기록
ord-808f51f1d05b4497b1c1c2c855bd4334
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08304412B2

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