Hydrochloric Acid → (4S,5R)-N-[(3-fluorophenyl)methyl]-4,5-diphenyl-4,5-dihydro-1H-imidazol-2-amine;hydrochloride

참여 물질

역할	이름	HCID	투입량
반응물	Hydrochloric Acid	HCID 313	—
반응물	tert-butyl (4S,5R)-2-[(3-fluorophenyl)methylamino]-4,5-diphenyl-4,5-dihydroimidazole-1-carboxylate	HCID 68569694	—
용매	Ethyl Acetate	HCID 8857	—
생성물	(4S,5R)-N-[(3-fluorophenyl)methyl]-4,5-diphenyl-4,5-dihydro-1H-imidazol-2-amine;hydrochloride	HCID 68569066	—

반응 단계

Hydrogen chloride is bubbled into a solution of 87 (1.5 g, 3.37 mmol) in EtOAc (30 mL) for 1 min, and the solution is stirred at RT overnight. The solvent is removed by rotary evaporation, and the residue crystallized from dichloromethane and Et2O to give 1.05 g of the product 88. 1H NMR (DMSO-d6) δ 9.28 (t, 1 H), 8.68 (s, 1 H), 8.15 (s, 1 H), 7.35-7.10 (m, 3 H), 7.10-6.80 (m, 7 H), 6.80-6.50 (m, 4 H), 5.03 (s, 1 H), 4.80-4.45 (m, 2 H); MS: m/z 346 (M++1).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07741493B2
출처 데이터셋	uspto-grants-2010_06
ORD ID	ord-e780e390a62e483688f5d057b78ce16a
출처 메모	uspto-grants-2010_06