Diisopropylcarbodiimide → HCID 68715436, 화합물

반응식

[O:1]([C:8]1[N:13]=[CH:12][C:11]([CH:14]=[CH:15][C:16]([OH:18])=O)=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C([N:22]=C=NC(C)C)(C)C.N1(O)C2C=CC=CC=2N=N1>CN(C=O)C>[O:1]([C:8]1[N:13]=[CH:12][C:11]([CH:14]=[CH:15][C:16]([NH2:22])=[O:18])=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

실험 절차

100 mg (0.415 mmol) of 3-(6-phenoxy-pyridin-3-yl)-acrylic acid was dissolved in 4 ml of DMF, and 52 mg (0.415 mmol) of N,N′-diisopropylcarbodiimide and 126 mg (0.830 mmol) of the ammonium salt of benzotriazol-1-ol were added. After 1 h a further 126 mg (0.830 mmol) of the ammonium salt of benzotriazol-1-ol were added. The reaction was stirred at room temperature for 16 h, filtered, and the product was purified by preparative RP HPLC eluting with a gradient of 0 to 100% acetonitrile in water (+0.01% TFA). After lyophilization, the product was obtained as a solid. Yield: 75 mg.