2,4-Dichloro-1-(1-methoxy-2-nitro-propyl)-benzene → 1-(2,4-Dichlorophenyl)-1-methoxypropan-2-amine
반응식
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH:9]([O:15][CH3:16])[CH:10]([N+:12]([O-])=O)[CH3:11]>C1COCC1.[Ni].CCO>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH:9]([O:15][CH3:16])[CH:10]([NH2:12])[CH3:11]참가 물질
4
실험 절차
2,4-dichloro-1-(1-methoxy-2-nitro-propyl)-benzene (132.2 g, 0.500 mol), was dissolved in THF (3.6 l). The solution was deaerated, RaNi-EtOH (133 g) catalyst was added, and the mixture was hydrogenated at 50 bar at ambient temperature for 23 hours. The catalyst was removed by filtration and the solvent was removed under reduced pressure. 117.1 g (100% of theory) of 2-(2,4-dichlorophenyl)-2-methoxy-1-methyl-ethylamine (compound Z1.14) was obtained in the form of a colourless oil as a mixture of diastereomeres.
후처리
- customThe catalyst was removed by filtration
- customthe solvent was removed under reduced pressure
출처 및 근거
- ORD 기록
- ord-b17ba39f1a224e61907c0bb15c8992e0
- 출처 데이터셋
- uspto-grants-2012_11
- 특허 번호
- US08304444B2
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