Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → (4S,5R)-N-[2-(2-fluorophenyl)ethyl]-4,5-diphenyl-4,5-dihydro-1H-imidazol-2-amine;hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | tert-butyl (4S,5R)-2-[2-(2-fluorophenyl)ethylamino]-4,5-diphenyl-4,5-dihydroimidazole-1-carboxylate | HCID 68570675 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | (4S,5R)-N-[2-(2-fluorophenyl)ethyl]-4,5-diphenyl-4,5-dihydro-1H-imidazol-2-amine;hydrochloride | HCID 68570205 | — |
반응 단계
Hydrogen chloride is bubbled into a solution of 91 (0.37 g, 0.81 mmol) in EtOAc (10 mL) for 1 min, and the solution is stirred at RT overnight. The solvent is removed by rotary evaporation, and the residue crystallized from dichloromethane and Et2O to give 0.21 g of the product 92. 1H NMR (DMSO-d6) δ 9.10 (t, 1 H), 8.43 (s, 1 H), 8.58 (s, 1 H), 7.40 (t, 1 H), 7.30-7.15 (m, 1 H), 7.15-6.90 (m, 8 H), 6.80-6.55 (m, 4 H), 5.15 (s, 2 H), 3.80-3.45 (m, 2 H), 3.10-2.85 (m, 2 H); MS: m/z 360 (M++1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07741493B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-69913a0ea6324408a51dd9aa7a98aa5c |
| 출처 메모 | uspto-grants-2010_06 |