2-Nitro-5-(3-nitrophenoxy)pyridine → 5-(3-Aminophenoxy)pyridin-2-amine

HRID 1874321

반응식

HRID 1874321 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([O:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([N+:17]([O-])=O)[CH:12]=2)=[CH:6][N:5]=1)([O-])=O>CO.[C].[Pd]>[NH2:17][C:13]1[CH:12]=[C:11]([CH:16]=[CH:15][CH:14]=1)[O:10][C:7]1[CH:8]=[CH:9][C:4]([NH2:1])=[N:5][CH:6]=1

참가 물질

4

반응물 1

HCID 577491152-Nitro-5-(3-nitrophenoxy)pyridine

생성물 1

HCID 577491665-(3-Aminophenoxy)pyridin-2-amine수율 96.1%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 887Methanol용매

실험 절차

To a solution of 2-nitro-5-(3-nitrophenoxy)pyridine (1.33 g, 5.07 mmol) in methanol (10 mL) was added palladium carbon (50% water-containing product, 100 mg), and the mixture was stirred under a hydrogen atmosphere at room temperature for 12 hr. The reaction mixture was filtered through celite, and the filtrate was concentrated under reduced pressure and dried to give the title compound (980 mg, 96%) as a yellow oil.

후처리

  1. filtrationThe reaction mixture was filtered through celite
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customdried

출처 및 근거

ORD 기록
ord-a81113a96572486e82148948405ef910
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08304557B2

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