Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydroxylamine HCl → Tert-butyl {3-[(2-amino[1,2,4]triazolo[1,5-a]pyridin-6-yl)oxy]-4-methylphenyl}carbamate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydroxylamine HCl | HCID 21645 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | Ethyl isothiocyanatoformate | HCID 85320 | — |
| 반응물 | Tert-butyl {3-[(6-aminopyridin-3-yl)oxy]-4-methylphenyl}carbamate | HCID 57749176 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | Tert-butyl {3-[(2-amino[1,2,4]triazolo[1,5-a]pyridin-6-yl)oxy]-4-methylphenyl}carbamate | HCID 57749391 | 87% |
반응 단계
In the same manner as in Example 17-1 and using tert-butyl {3-[(6-aminopyridin-3-yl)oxy]-4-methylphenyl}carbamate (1.69 g, 5.35 mmol), DMSO (5 mL), ethyl isothiocyanatoformate (843 mg, 6.42 mmol), ethanol (20 mL), methanol (20 mL), hydroxylammonium chloride (2.43 g, 35.0 mmol) and N,N-diisopropylethylamine (4.35 mL, 25.0 mmol) as starting materials, the title compound (1.55 g, 87%) was obtained as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08304557B2 |
| 출처 데이터셋 | uspto-grants-2012_11 |
| ORD ID | ord-4db9f563c2f542eb90a1e5ba9c8f4e56 |
| 출처 메모 | uspto-grants-2012_11 |