Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Tetrahydrofuran → 4-chloro-N-[3-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)phenyl]-1-methyl-1H-pyrazole-3-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | Oxalyl chloride | HCID 65578 | — |
| 반응물 | 4-Chloro-1-methyl-1H-pyrazole-3-carboxylic acid | HCID 594685 | — |
| 반응물 | N-[6-(3-aminophenoxy)[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide | HCID 57749117 | — |
| 촉매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Dimethylacetamide | HCID 31374 | — |
| 생성물 | 4-chloro-N-[3-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)phenyl]-1-methyl-1H-pyrazole-3-carboxamide | HCID 57749290 | 45.2% |
반응 단계
In the same manner as in Example 18-4 and using 4-chloro-1-methyl-1H-pyrazole-3-carboxylic acid (156 mg, 0.970 mmol), tetrahydrofuran (7 mL), oxalyl chloride (93.0 μL, 1.07 mmol), N-[6-(3-aminophenoxy)[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide (200 mg, 0.646 mmol), N,N-dimethylformamide (1 drop) and N,N-dimethylacetamide (5 mL) as starting materials, the title compound (132 mg, 45%) was obtained as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08304557B2 |
| 출처 데이터셋 | uspto-grants-2012_11 |
| ORD ID | ord-157815053f0a495cafe6994412546d1d |
| 출처 메모 | uspto-grants-2012_11 |