Cyclopropanecarbonyl chloride → HCID 57749388, 화합물

HRID 1874509노트

반응식

HRID 1874509 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([CH:18]=[CH:19][CH:20]=1)[O:7][C:8]1[CH:13]=[CH:12][N:11]2[N:14]=[C:15]([NH2:17])[N:16]=[C:10]2[CH:9]=1)([O-:3])=[O:2].[CH:21]1([C:24](Cl)=[O:25])[CH2:23][CH2:22]1>CN(C)C(=O)C>[N+:1]([C:4]1[CH:5]=[C:6]([CH:18]=[CH:19][CH:20]=1)[O:7][C:8]1[CH:13]=[CH:12][N:11]2[N:14]=[C:15]([NH:17][C:24]([CH:21]3[CH2:23][CH2:22]3)=[O:25])[N:16]=[C:10]2[CH:9]=1)([O-:3])=[O:2]

참가 물질

4

반응물 2

HCID 77637Cyclopropanecarbonyl chlorideHCID 57749227HCID 57749227, 화합물

생성물 1

HCID 57749388HCID 57749388, 화합물수율 96%

시약·촉매·용매 1

HCID 31374Dimethylacetamide용매

실험 절차

In the same manner as in Example 18-2 and using 7-(3-nitrophenoxy)[1,2,4]triazolo[1,5-a]pyridin-2-amine (112 mg, 0.413 mmol), cyclopropanecarbonyl chloride (135 μL, 0.496 mmol) and N,N-dimethylacetamide (5 mL) as starting materials, the title compound (134 mg, 96%) was obtained as a white solid.

출처 및 근거

ORD 기록
ord-5eb066f9d6c64770b60196bd7ad3503b
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08304557B2

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