Chlorosuccinimide → HCID 178454347, 화합물

HRID 1875063노트

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HRID 1875063 반응식
[Cl:1]N1C(=O)CCC1=O.[CH3:9][C:10]([O:13][C:14]([N:16]([C:24]1[NH:25][CH:26]=[C:27]([CH:29]=[O:30])[N:28]=1)[C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])=[O:15])([CH3:12])[CH3:11]>C(#N)C>[CH3:12][C:10]([O:13][C:14]([N:16]([C:24]1[NH:28][C:27]([CH:29]=[O:30])=[C:26]([Cl:1])[N:25]=1)[C:17]([O:19][C:20]([CH3:21])([CH3:22])[CH3:23])=[O:18])=[O:15])([CH3:9])[CH3:11]

참가 물질

4

반응물 2

HCID 31398ChlorosuccinimideHCID 178454349HCID 178454349, 화합물

생성물 1

HCID 178454347HCID 178454347, 화합물수율 11.5%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

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온도
60 °C

실험 절차

N-Chlorosuccinimide (0.346 g, 2.59 mmol) was added to a suspension of bis(1,1-dimethylethyl)(4-formyl-1H-imidazol-2-yl)imidodicarbonate (0.672 g, 2.158 mmol) in acetonitrile (10 mL). The mixture was heated at 60° C. for 2 hrs. The solvent was evaporated. Chromatography of the residue with ethyl acetate:hexane gave the title compound (0.086 g, 11%) as a white solid. 1H NMR (400 MHz, chloroform-d) δ ppm 10.38-10.79 (m, 1H), 9.6 (s, 1H), 1.52 (s, 18H). ES MS: m/z 345

후처리

  1. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-629ea1e83bdc44b1b8ab43a9d88aa9dd
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08304419B2

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