To a solution of N-({3-[(3-bromo-5-cyanophenyl)oxy]-4-chloro-2-fluorophenyl}methyl)-4-chloro-1H-imidazole-5-carboxamide (95 mg, 0.196 mmol), Palladium dichloropistriphenylphosphine (103 mg, 0.196 mmol), 3-methyl-1-butyne (26.7 mg, 0.392 mmol) and copper(I) iodide (1.869 mg, 9.81 μmol) in THF (4 ml) was added TEA (0.141 ml, 1.012 mmol) and the reaction mixture was irradiated in a personal microwave reactor for 10 minutes at 120° C. The solvent was removed and the crude material was purified via reverse phase HPLC to give 4-chloro-N-[(4-chloro-3-{[3-cyano-5-(3-methyl-1-butyn-1-yl)phenyl]oxy}-2-fluorophenyl)methyl]-1H-imidazole-5-carboxamide (49 mg, 0.104 mmol, 53% yield). 1H NMR (400 MHz, DMSO-d6) δ ppm 8.25 (d, 1H), 7.73 (s, 1H), 7.57 (s, 1H), 7.41-7.50 (m, 2H), 7.32 (t, 1H), 7.11 (s, 1H), 4.49 (d, 2H), 2.76 (dt, 1H), 1.15 (d, 6H). LC-MS (ES+) m/z 471.13, [M+H].
