Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diphenylsilane → Methyl (R)-2,3-dimethyl-1,2,3,4-tetrahydroisoquinoline-6-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diphenylsilane | HCID 69888 | — |
| 반응물 | methyl (R)-2,3-dimethyl-1-oxo-1,2,3,4-tetrahydroisoquinoline-6-carboxylate | HCID 86761672 | — |
| 촉매 | Carbonylhydridotris(triphenylphosphine)rhodium(I) | HCID 10941995 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | Methyl (R)-2,3-dimethyl-1,2,3,4-tetrahydroisoquinoline-6-carboxylate | HCID 86761671 | — |
반응 단계
60 mg (257 μmol) methyl (R)-2,3-dimethyl-1-oxo-1,2,3,4-tetrahydroisoquinoline-6-carboxylate are dissolved in 2 ml THF under an argon atmosphere and at RT combined with 100 μl (542 μmol) diphenylsilane. Then 20 mg (21 μmol) carbonylhydridotris(triphenylphosphine)rhodium(I) are added and the mixture is stirred for two hours. A further 50 μl diphenylsilane and 10 mg carbonylhydridotris(triphenylphosphine)rhodium(I) are added and the mixture is stirred for a further 2.5 hours. Then the reaction mixture is evaporated down i. vac. and purified by flash chromatography on silica gel (eluant DCM/MeOH 95:5).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08309542B2 |
| 출처 데이터셋 | uspto-grants-2012_11 |
| ORD ID | ord-aecf0787748f46eabe57a4dd91f97eba |
| 출처 메모 | uspto-grants-2012_11 |