Acetic Acid → 2-(2-Nitro-1-propen-1-yl)thiophene

반응식

C([C:3]1[CH:7]=[CH:6][S:5][CH:4]=1)=O.[N+:8]([CH2:11][CH3:12])([O-:10])=[O:9].[CH2:13](N)CCC.C(O)(=O)C>>[N+:8]([C:11]([CH3:13])=[CH:12][C:6]1[S:5][CH:4]=[CH:3][CH:7]=1)([O-:10])=[O:9]

참가 물질

반응물 4

HCID 176Acetic Acid

HCID 6587Nitroethane

HCID 8007Butylamine

HCID 681353-Thiophenecarboxaldehyde

생성물 1

HCID 2382342-(2-Nitro-1-propen-1-yl)thiophene

반응 조건

온도: 80 °C

실험 절차

5.0 g (44.6 mmol) 3-formylthiophene are dissolved together with 8.9 ml (124.8 mmol) nitroethane, 5.3 ml (53.5 mmol) butylamine in 25.1 ml glacial acetic acid (454.7 mmol) and heated to 80° C. After two hours the mixture is cooled and the precipitate formed is suction filtered and washed with copious amounts of water. The crude product thus obtained is dissolved in ethyl acetate, dried on sodium sulphate and evaporated down i. vac.