Sodium Methoxide → HCID 23144869, 화합물

HRID 1875560노트

반응식

HRID 1875560 반응식
C[O-].[Na+].Br[CH2:5][C:6]1[C:7]([N+:16]([O-:18])=[O:17])=[C:8]([CH:13]=[CH:14][CH:15]=1)[C:9]([O:11][CH3:12])=[O:10].[O:19]1CCOC[CH2:20]1.Cl>CO>[CH3:20][O:19][CH2:5][C:6]1[C:7]([N+:16]([O-:18])=[O:17])=[C:8]([CH:13]=[CH:14][CH:15]=1)[C:9]([O:11][CH3:12])=[O:10]

참가 물질

5

반응물 3

HCID 10942334Sodium MethoxideHCID 204431481,4-Dioxane hydrochlorideHCID 22509333Methyl 3-(bromomethyl)-2-nitrobenzoate

생성물 1

HCID 23144869HCID 23144869, 화합물

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

Methanol solution (4.7 mL) of sodium methoxide (197 mg) was added dropwise into the mixture of methyl 3-bromomethyl-2-nitrobenzoate (1 g) and methanol (7 mL) under heating and refluxing. Two minutes later, the mixture was cooled down with ice and 1.82 mL of 4M hydrogen chloride dioxane solution was added dropwise thereto. After removing the solvent, diethylether and water were added and the organic layer thereof was dried over sodium sulfate. After removing the solvent, the obtained residue was purified with silica gel column chromatography to obtain 621 mg of methyl 3-methoxymethyl-2-nitrobenzoate.

후처리

  1. temperatureunder heating
  2. temperaturerefluxing
  3. additionwas added dropwise
  4. customAfter removing the solvent, diethylether and water
  5. additionwere added
  6. dry with materialthe organic layer thereof was dried over sodium sulfate
  7. customAfter removing the solvent
  8. customthe obtained residue was purified with silica gel column chromatography

출처 및 근거

ORD 기록
ord-4740903a398f405eb2e1492264a24046
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08309561B2

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