(R)-3-(2-(2-(hydroxymethyl)pyrrolidin-1-yl)ethyl)-5-methylisoquinolin-1(2H)-one → (R)-3-[2-(2-hydroxymethylpyrrolidin-1-yl)ethyl]-5-methyl-2H-isoquinolin-1-one mono-D-tartrate monohydrate

HRID 1875704노트

반응식

HRID 1875704 반응식
[OH:1][CH2:2][C@H:3]1[CH2:7][CH2:6][CH2:5][N:4]1[CH2:8][CH2:9][C:10]1[NH:11][C:12](=[O:21])[C:13]2[C:18]([CH:19]=1)=[C:17]([CH3:20])[CH:16]=[CH:15][CH:14]=2.C(O)C.[C:25]([OH:34])(=[O:33])[C@H:26]([C@@H:28]([C:30]([OH:32])=[O:31])[OH:29])[OH:27]>C(O)C>[OH2:1].[C:30]([C@H:28]([C@@H:26]([C:25]([OH:34])=[O:33])[OH:27])[OH:29])([OH:32])=[O:31].[OH:1][CH2:2][C@H:3]1[CH2:7][CH2:6][CH2:5][N:4]1[CH2:8][CH2:9][C:10]1[NH:11][C:12](=[O:21])[C:13]2[C:18]([CH:19]=1)=[C:17]([CH3:20])[CH:16]=[CH:15][CH:14]=2

참가 물질

4

반응물 2

HCID 10424118(R)-3-(2-(2-(hydroxymethyl)pyrrolidin-1-yl)ethyl)-5-methylisoquinolin-1(2H)-oneHCID 86653873D-tartaric acid ethanol

생성물 1

HCID 86653872(R)-3-[2-(2-hydroxymethylpyrrolidin-1-yl)ethyl]-5-methyl-2H-isoquinolin-1-one mono-D-tartrate monohydrate

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution (500 mL) of a free form (51 mg) of (R)-3-[2-(2-hydroxymethylpyrrolidin-1-yl)ethyl]-5-methyl-2H-isoquinolin-1-one in ethanol was added dropwise 100 mg/mL D-tartaric acid ethanol solution (272 μL) under ice-cooling with stirring and the mixture was left standing for 1 hr. The resulting precipitate was collected by filtration, washed with cold ethanol (2 mL) and dried under reduced pressure at 40° C. for 4 hr to give the title compound (74 mg).

후처리

  1. temperaturecooling
  2. waitthe mixture was left
  3. filtrationThe resulting precipitate was collected by filtration
  4. washwashed with cold ethanol (2 mL)
  5. customdried under reduced pressure at 40° C. for 4 hr

출처 및 근거

ORD 기록
ord-739fb24466dc40f4b8c98ecf42eb67c6
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08309573B2

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