Dimethylformamide → 2-(4-Cyano-2-fluoro-phenoxymethyl)-benzoyl chloride

HRID 1875771노트

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HRID 1875771 반응식
[C:1]([C:3]1[CH:19]=[CH:18][C:6]([O:7][CH2:8][C:9]2[CH:17]=[CH:16][CH:15]=[CH:14][C:10]=2[C:11](O)=[O:12])=[C:5]([F:20])[CH:4]=1)#[N:2].C(Cl)(=O)C([Cl:24])=O.CN(C)C=O>ClCCl>[C:1]([C:3]1[CH:19]=[CH:18][C:6]([O:7][CH2:8][C:9]2[CH:17]=[CH:16][CH:15]=[CH:14][C:10]=2[C:11]([Cl:24])=[O:12])=[C:5]([F:20])[CH:4]=1)#[N:2]

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 670499362-(4-Cyano-2-fluoro-phenoxymethyl)-benzoic acid

생성물 1

HCID 866522892-(4-Cyano-2-fluoro-phenoxymethyl)-benzoyl chloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

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온도
25 °C

실험 절차

To a suspension of 2-(4-cyano-2-fluoro-phenoxymethyl)-benzoic acid (1.0 g, 3.68 mmol) in dichloromethane (15 ml) was added oxalyl chloride (0.45 ml, 4.79 mmol), followed by a drop of N,N-dimethylformamide, and stirred for 12 h at 25° C. The resulting clear solution was evaporated in vacuo and the crude product was used in the next step without any further purification (99%). MS (Turbo Spray): m/z=290.1 (M+H).

후처리

  1. customThe resulting clear solution was evaporated in vacuo
  2. customthe crude product was used in the next step without any further purification (99%)

출처 및 근거

ORD 기록
ord-380d637c91bf427e90260c6a7934c9ee
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08309581B2

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