4-(Bromomethyl)-3-fluorobenzonitrile → HCID 67049937, 화합물

반응식

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:9]2[N:13]([CH2:14][C:15]([CH3:18])([CH3:17])[CH3:16])[C:12]3[CH:19]=[C:20]([F:24])[C:21]([F:23])=[CH:22][C:11]=3[N:10]=2)=[C:6]([OH:8])[CH:7]=1.Br[CH2:26][C:27]1[CH:34]=[CH:33][C:30]([C:31]#[N:32])=[CH:29][C:28]=1[F:35]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:9]2[N:13]([CH2:14][C:15]([CH3:18])([CH3:17])[CH3:16])[C:12]3[CH:19]=[C:20]([F:24])[C:21]([F:23])=[CH:22][C:11]=3[N:10]=2)=[C:6]([CH:7]=1)[O:8][CH2:26][C:27]1[CH:34]=[CH:33][C:30]([C:31]#[N:32])=[CH:29][C:28]=1[F:35]

참가 물질

반응물 2

HCID 27831494-(Bromomethyl)-3-fluorobenzonitrile

HCID 136378488HCID 136378488, 화합물

생성물 1

HCID 67049937HCID 67049937, 화합물

실험 절차

The title compound was prepared in analogy to Example 5, intermediate a, from 5-chloro-2-[1-(2,2-dimethyl-propyl)-5,6-difluoro-1H-benzoimidazol-2-yl]-phenol and 4-bromomethyl-3-fluoro-benzonitrile (CAS Reg. No. 105942-09-4). Light brown solid (95%). MS (Turbo Spray): m/z=483.8 (M+H).

출처 및 근거

ORD 기록: ord-57baf38d16024311a7754f74d4622eb3
출처 데이터셋: uspto-grants-2012_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08309581B2

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