(Bromomethyl)cyclopentane → HCID 67049856, 화합물

반응식

[CH3:1][O:2][C:3](=[O:30])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10][N:11]2[C:15]3[CH:16]=[C:17]([F:21])[C:18]([F:20])=[CH:19][C:14]=3[N:13]=[C:12]2[C:22]2[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][C:23]=2[OH:29])[CH:5]=1.Br[CH2:32][CH:33]1[CH2:37][CH2:36][CH2:35][CH2:34]1>>[CH3:1][O:2][C:3](=[O:30])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10][N:11]2[C:15]3[CH:16]=[C:17]([F:21])[C:18]([F:20])=[CH:19][C:14]=3[N:13]=[C:12]2[C:22]2[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][C:23]=2[O:29][CH2:32][CH:33]2[CH2:37][CH2:36][CH2:35][CH2:34]2)[CH:5]=1

참가 물질

반응물 2

HCID 12723264(Bromomethyl)cyclopentane

HCID 136378486HCID 136378486, 화합물

생성물 1

HCID 67049856HCID 67049856, 화합물

실험 절차

The title compound was prepared in analogy to Example 5, intermediate a, from 3-[2-(4-chloro-2-hydroxy-phenyl)-5,6-difluoro-benzoimidazol-1-ylmethyl]-benzoic acid methyl ester and bromomethyl-cyclopentane (CAS Reg. No. 3814-30-0). Brown sticky solid (72%). MS (Turbo Spray): m/z=511.2 (M+H).

출처 및 근거

ORD 기록: ord-0fa10cb160bc400e949a438574021535
출처 데이터셋: uspto-grants-2012_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08309581B2

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