1,1'-Thiocarbonyldi-2(1H)-pyridone → 4-Isothiocyanato-6-(3-methoxyphenyl)pyrimidine

HRID 1875920

반응식

HRID 1875920 반응식
[C:1](N1C=CC=CC1=O)(N1C=CC=CC1=O)=[S:2].[CH3:17][O:18][C:19]1[CH:20]=[C:21]([C:25]2[N:30]=[CH:29][N:28]=[C:27]([NH2:31])[CH:26]=2)[CH:22]=[CH:23][CH:24]=1>ClCCl>[N:31]([C:27]1[CH:26]=[C:25]([C:21]2[CH:22]=[CH:23][CH:24]=[C:19]([O:18][CH3:17])[CH:20]=2)[N:30]=[CH:29][N:28]=1)=[C:1]=[S:2]

참가 물질

4

반응물 2

HCID 8531621,1'-Thiocarbonyldi-2(1H)-pyridoneHCID 497584386-(3-Methoxyphenyl)pyrimidin-4-amine

생성물 1

HCID 574765634-Isothiocyanato-6-(3-methoxyphenyl)pyrimidine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 1,1′-thiocarbonyldipyridin-2(1H)-one (0.970 g, 4.17 mmol) in dichloromethane at room temperature was added 6-(3-methoxyphenyl)pyrimidin-4-amine (0.7 g, 3.48 mmol). The reaction was stirred at room temperature for 18 hours. The LC/MS showed the desired product peak as a major peak. The deep orange solution was concentrated and the remaining residue was filtered. The filtrate was purified by silica gel chromatography (0-10% ethyl acetate-hexanes) to afford 4-isothiocyanato-6-(3-methoxyphenyl)pyrimidine (0.39 g, 4.31 mmol, 46% yield) as a yellow oil. LCMS R.T.=2.91; [M+H]+=244.03.

출처 및 근거

ORD 기록
ord-a7f0fd1020534ec7bbbc8bfeb0c3a096
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08309577B2

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