1,8-Diazabicyclo(5.4.0)undec-7-ene → HCID 86646305, 화합물

HRID 1876280노트

반응식

HRID 1876280 반응식
C1(P([N:15]=[N+:16]=[N-:17])(C2C=CC=CC=2)=O)C=CC=CC=1.N12CCCN=C1CCCCC2.[Cl:29][C:30]1[CH:39]=[C:38]2[C:33]([CH:34]=[CH:35][CH:36]=[C:37]2[CH2:40]O)=[CH:32][CH:31]=1>C1(C)C=CC=CC=1>[N:15]([CH2:40][C:37]1[C:38]2[C:33](=[CH:32][CH:31]=[C:30]([Cl:29])[CH:39]=2)[CH:34]=[CH:35][CH:36]=1)=[N+:16]=[N-:17]

참가 물질

5

반응물 3

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 199401P,P-Diphenylphosphinic azideHCID 68697042HCID 68697042, 화합물

생성물 1

HCID 86646305HCID 86646305, 화합물

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

1.52 ml of Diphenylphosphoryl azide and 1.10 ml of 1,8-diazabicyclo[5.4.0]undec-7-ene are added to 1.3 g of (7-Chloro-naphthalen-1-yl)-methanol in 18 ml of toluene. The mixture obtained is stirred at rt for 1 hour, washed with brine, the organic phase is dried and solvent is evaporated. The residue obtained is purified by flash chromatography on silica gel (eluent: cyclohexane/EtOAc 99/1) to yield the title compound.

후처리

  1. customThe mixture obtained
  2. washwashed with brine
  3. customthe organic phase is dried
  4. customsolvent is evaporated
  5. customThe residue obtained
  6. customis purified by flash chromatography on silica gel (eluent: cyclohexane/EtOAc 99/1)

출처 및 근거

ORD 기록
ord-b045cfdf220a43718220c8c78611f6a2
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08309596B2

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