Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(2-(4-Nitrophenoxy)ethyl)pyrrolidine → 4-(2-(Pyrrolidin-1-yl)ethoxy)aniline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(2-(4-Nitrophenoxy)ethyl)pyrrolidine | HCID 419858 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 4-(2-(Pyrrolidin-1-yl)ethoxy)aniline | HCID 6493749 | — |
반응 단계
A mixture of 1-[2-(4-nitrophenoxy)ethyl]pyrrolidine (from Combi-Blocks, LLC, 5.00 g, 0.0212 mol) in 100 mL of MeOH was hydrogenated in the presence of 0.5 g 10% Pd/C, under balloon pressure of hydrogen, overnight. After filtering off the catalyst, the filtrate was evaporated to dryness and used directly in next step (4.36 g, 99.88%). LCMS (M+H) 207.4.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08309718B2 |
| 출처 데이터셋 | uspto-grants-2012_11 |
| ORD ID | ord-d9bda850dfd74ef182f43c6f143b8063 |
| 출처 메모 | uspto-grants-2012_11 |