Ethyl 3-(methylamino)propanoate → HCID 59529322, 화합물

반응식

[CH2:1]([C:3]1[O:4][C:5]([C:20]2[CH:25]=[CH:24][C:23]([C:26]([F:29])([F:28])[F:27])=[CH:22][CH:21]=2)=[CH:6][C:7]=1[CH:8]([O:10][C:11]1[CH:19]=[CH:18][C:14]([C:15](O)=[O:16])=[CH:13][CH:12]=1)[CH3:9])[CH3:2].[CH3:30][NH:31][CH2:32][CH2:33][C:34]([O:36]CC)=[O:35]>>[CH2:1]([C:3]1[O:4][C:5]([C:20]2[CH:21]=[CH:22][C:23]([C:26]([F:28])([F:29])[F:27])=[CH:24][CH:25]=2)=[CH:6][C:7]=1[CH:8]([O:10][C:11]1[CH:19]=[CH:18][C:14]([C:15]([N:31]([CH3:30])[CH2:32][CH2:33][C:34]([OH:36])=[O:35])=[O:16])=[CH:13][CH:12]=1)[CH3:9])[CH3:2]

참가 물질

반응물 2

HCID 541480Ethyl 3-(methylamino)propanoate

HCID 68512355HCID 68512355, 화합물

생성물 1

HCID 59529322HCID 59529322, 화합물수율 99%

실험 절차

An operation similar to that in Example 1 (4) was performed using 4-(1-{2-ethyl-5-[4-(trifluoromethyl)phenyl]-3-furyl}ethoxy)benzoic acid (121 mg) as well as ethyl 3-(methylamino)propanoate (47 mg) to give the title compound (145 mg, 99%) as an oil.

출처 및 근거

ORD 기록: ord-c8458ced17854459a9591c36d926e09e
출처 데이터셋: uspto-grants-2012_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08309580B2

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