2-Ethyl-5-[4-(trifluoromethyl)phenyl]-3-furaldehyde → 1-{2-Ethyl-5-[4-(trifluoromethyl)phenyl]-3-furyl}-3-methylbutan-1-ol

HRID 1876940

반응식

HRID 1876940 반응식
[CH2:1]([C:3]1[O:4][C:5]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][CH:11]=2)=[CH:6][C:7]=1[CH:8]=[O:9])[CH3:2].[CH2:20]([Mg]Br)[CH:21]([CH3:23])[CH3:22].O1CCCC1>>[CH2:1]([C:3]1[O:4][C:5]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:17])[F:18])=[CH:12][CH:11]=2)=[CH:6][C:7]=1[CH:8]([OH:9])[CH2:20][CH:21]([CH3:23])[CH3:22])[CH3:2]

참가 물질

3

반응물 2

HCID 230743552-Ethyl-5-[4-(trifluoromethyl)phenyl]-3-furaldehydeHCID 178420648HCID 178420648, 화합물

생성물 1

HCID 685133441-{2-Ethyl-5-[4-(trifluoromethyl)phenyl]-3-furyl}-3-methylbutan-1-ol수율 83%

실험 절차

An operation similar to that in Example 3 (2) was performed using 2-ethyl-5-[4-(trifluoromethyl)phenyl]-3-furaldehyde (805 mg) and 1N isobutylmagnesium bromide-tetrahydrofuran solution (6.0 mL) to give the title compound (819 mg, 83%) as an oil.

출처 및 근거

ORD 기록
ord-f48eec13cb6e43389fa47c6a5b98254b
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08309580B2

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