5-(4-Chlorophenyl)-2-methyl-3-furaldehyde → [5-(4-Chlorophenyl)-2-methyl-3-furyl](cyclohexyl)methanol

HRID 1876959

반응식

HRID 1876959 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][C:11]([CH3:13])=[C:10]([CH:14]=[O:15])[CH:9]=2)=[CH:4][CH:3]=1.[CH:16]1([Mg]Br)[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1.O1CCCC1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][C:11]([CH3:13])=[C:10]([CH:14]([CH:16]3[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]3)[OH:15])[CH:9]=2)=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 219864715-(4-Chlorophenyl)-2-methyl-3-furaldehydeHCID 178420632HCID 178420632, 화합물

생성물 1

HCID 68509840[5-(4-Chlorophenyl)-2-methyl-3-furyl](cyclohexyl)methanol수율 83%

실험 절차

An operation similar to that in Example 3 (2) was performed using 5-(4-chlorophenyl)-2-methyl-3-furaldehyde (1.7 g) and 1N cyclohexylmagnesium bromide-tetrahydrofuran solution (15 mL) to give the title compound (2.0 g, 83%) as a white crystal.

출처 및 근거

ORD 기록
ord-922c2f337ed144208328425921ca39fd
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08309580B2

연결된 노트

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