2-Ethyl-5-[4-(trifluoromethyl)phenyl]-3-furaldehyde → {2-Ethyl-5-[4-(trifluoromethyl)phenyl]-3-furyl}(phenyl)methanol

HRID 1876961

반응식

HRID 1876961 반응식
[CH2:1]([C:3]1[O:4][C:5]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][CH:11]=2)=[CH:6][C:7]=1[CH:8]=[O:9])[CH3:2].[C:20]1([Mg]Br)[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.O1CCCC1>>[CH2:1]([C:3]1[O:4][C:5]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:17])[F:18])=[CH:12][CH:11]=2)=[CH:6][C:7]=1[CH:8]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[OH:9])[CH3:2]

참가 물질

3

반응물 2

HCID 230743552-Ethyl-5-[4-(trifluoromethyl)phenyl]-3-furaldehydeHCID 178420626HCID 178420626, 화합물

생성물 1

HCID 68511675{2-Ethyl-5-[4-(trifluoromethyl)phenyl]-3-furyl}(phenyl)methanol수율 87%

실험 절차

An operation similar to that in Example 3 (2) was performed using 2-ethyl-5-[4-(trifluoromethyl)phenyl]-3-furaldehyde (1.0 g) and 1N phenylmagnesium bromide-tetrahydrofuran solution (8.0 mL) to give the title compound (1.2 g, 87%) as a yellow crystal.

출처 및 근거

ORD 기록
ord-7f9bfd3590654431beeac520ab741d46
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08309580B2

연결된 노트

불러오는 중…