(4-Fluoro-2-methylphenyl)boronic acid → Methyl 5-(4-fluoro-2-methylphenyl)-2-methyl-3-furoate

HRID 1876977

반응식

HRID 1876977 반응식
Br[C:2]1[O:6][C:5]([CH3:7])=[C:4]([C:8]([O:10][CH3:11])=[O:9])[CH:3]=1.[F:12][C:13]1[CH:18]=[CH:17][C:16](B(O)O)=[C:15]([CH3:22])[CH:14]=1>>[F:12][C:13]1[CH:18]=[CH:17][C:16]([C:2]2[O:6][C:5]([CH3:7])=[C:4]([C:8]([O:10][CH3:11])=[O:9])[CH:3]=2)=[C:15]([CH3:22])[CH:14]=1

참가 물질

3

반응물 2

HCID 2734665(4-Fluoro-2-methylphenyl)boronic acidHCID 15534190Methyl 5-bromo-2-methylfuran-3-carboxylate

생성물 1

HCID 68515415Methyl 5-(4-fluoro-2-methylphenyl)-2-methyl-3-furoate수율 85%

실험 절차

An operation similar to that in Example 49 (2) was performed using methyl 5-bromo-2-methyl-3-furoate (4.4 g) and 4-fluoro-2-methylphenylboronic acid (3.7 g) to give the title compound (4.2 g, 85%) as a white crystal.

출처 및 근거

ORD 기록
ord-e0684a6fff9347809873f7e39b59413b
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08309580B2

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