5-(4-Fluoro-2-methylphenyl)-2-methyl-3-furaldehyde → Cyclohexyl[5-(4-fluoro-2-methylphenyl)-2-methyl-3-furyl]methanol

HRID 1876978

반응식

HRID 1876978 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][C:11]([CH3:13])=[C:10]([CH:14]=[O:15])[CH:9]=2)=[C:4]([CH3:16])[CH:3]=1.[CH:17]1([Mg]Br)[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1.O1CCCC1>>[CH:17]1([CH:14]([C:10]2[CH:9]=[C:8]([C:5]3[CH:6]=[CH:7][C:2]([F:1])=[CH:3][C:4]=3[CH3:16])[O:12][C:11]=2[CH3:13])[OH:15])[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1

참가 물질

3

반응물 2

HCID 866463675-(4-Fluoro-2-methylphenyl)-2-methyl-3-furaldehydeHCID 178420632HCID 178420632, 화합물

생성물 1

HCID 68515490Cyclohexyl[5-(4-fluoro-2-methylphenyl)-2-methyl-3-furyl]methanol수율 72%

실험 절차

An operation similar to that in Example 3 (2) was performed using 5-(4-fluoro-2-methylphenyl)-2-methyl-3-furaldehyde (2.6 g) and 1N cyclohexylmagnesium bromide-tetrahydrofuran solution (18 mL) to give the title compound (2.6 g, 72%) as an oil.

출처 및 근거

ORD 기록
ord-16a088323c3a4b889b0e46625ec3144b
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08309580B2

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